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Brain mapping reveals cell

Like previous studies, the initial results showed a decrease in the activity of genes associated with neuronal circuits. These decreases were seen in neurons, the primary circuitry cells, as well as in “glial” cells called astrocytes and oligodendrocytes, which can support neural signaling by controlling neurotransmitter levels and electrically insulating nerve fibers. In contrast, aging […]

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Brain mapping reveals cell


Like previous studies, the initial results showed a decrease in the activity of genes associated with neuronal circuits. These decreases were seen in neurons, the primary circuitry cells, as well as in “glial” cells called astrocytes and oligodendrocytes, which can support neural signaling by controlling neurotransmitter levels and electrically insulating nerve fibers. In contrast, aging increased the activity of genes associated with the brain’s immunity and inflammatory systems, as well as brain blood vessel cells.

The authors noted that these observations align with previous studies on several different animals that showed links between aging and body metabolism, including those on how intermittent fasting and other calorie restricting diets can increase life span. Specifically, the age-sensitive neurons in the hypothalamus are known to produce feeding and energy-controlling hormones while the ventricle-lining cells control the passage of hormones and nutrients between the brain and the body. More research is needed to examine the biological mechanisms underlying the findings, as well as search for any possible links to human health. 

“Aging is the most important risk factor for Alzheimer’s disease and many other devastating brain disorders. These results provide a highly detailed map for which brain cells may be most affected by aging,” said Richard J. Hodes, M.D., director of NIH’s National Institute on Aging.

Further analysis helped spot which cell types may be the most sensitive to aging. For example, the results suggested that aging reduces the development of newborn neurons found in at least three different parts of the brain. Previous studies have shown that some of these newborn neurons may play a role in the circuitry that controls some forms of learning and memory while others may help mice recognize different smells.

Richard J. Hodes, M.D., Director, National Institute on Aging

The cells that appeared to be the most sensitive to aging surround the third ventricle, a major pipeline that enables cerebrospinal fluid to pass through the hypothalamus. Located at the base of the mouse brain, the hypothalamus produces hormones that can control the body’s basic needs, including temperature, heart rate, sleep, thirst, and hunger. The results showed that cells lining the third ventricle and neighbouring neurons in the hypothalamus had the greatest changes in genetic activity with age, including increases in immunity genes and decreases in genes associated with neuronal circuitry.

This new map may fundamentally alter the way scientists think about how aging affects the brain and also provide a guide for developing new treatments for aging-related brain diseases.”

Based on new brain mapping research funded by the National Institutes of Health (NIH), scientists have discovered that not all cell types in the brain age in the same way. They found that some cells, such as a small group of hormone-controlling cells, may undergo more age-related changes in genetic activity than others. The results, published in Nature, support the idea that some cells are more sensitive to the aging process and aging brain disorders than others.

Scientists used advanced genetic analysis tools to study individual cells in the brains of 2-month-old “young” and 18-month-old “aged” mice. For each age, researchers analysed the genetic activity of a variety of cell types located in 16 different broad regions -; constituting 35% of the total volume of a mouse brain.

Jin, K., et al. (2025). Brain-wide cell-type-specific transcriptomic signatures of healthy ageing in mice. Nature. doi.org/10.1038/s41586-024-08350-8.
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Public wants transgender athletes to stick with birth

(TNND) — Most Americans believe transgender athletes should only be allowed to play on teams that match their sex at birth, a new poll from Gallup found. And Gallup found the public is less supportive of transgender athletes than they were several years ago. Today, 69% of Americans believe transgender athletes should only be allowed […]

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Public wants transgender athletes to stick with birth

Most Americans believe transgender athletes should only be allowed to play on teams that match their sex at birth, a new poll from Gallup found.

And Gallup found the public is less supportive of transgender athletes than they were several years ago.

Today, 69% of Americans believe transgender athletes should only be allowed to play on teams that match their birth gender.

Support for allowing people to play on teams based on their gender identity has dropped 10 percentage points over the last four years, standing now at 24%.

President Donald Trump signed an executive order in early February aimed at barring transgender female athletes from competing in women’s or girls’ sports.

Gallup noted that Trump has also signed executive orders eliminating federal recognition of gender identity, banning transgender individuals from serving in the military, and restricting access to gender-affirming health care for minors.

Peter Loge, the director of the School of Media and Public Affairs at George Washington University, said transgender issues have become more prominent in the political discourse.

And Trump has become a leading voice in that discourse.

Loge said Trump has put transgender issues on the agenda, because he knows those are political winners for him.

Trump’s influence might be reflected in the Gallup survey data, which shows a more conservative trend toward the topic.

For example, just 9% of Republicans told Gallup that it’s morally acceptable for a person to change their gender.

Nearly a quarter of Republicans felt that way in 2021.

Overall, 40% of Americans said it’s morally acceptable for a person to change their gender, down six percentage points from four years earlier.

About seven in 10 Democrats said it was morally acceptable for a person to change their gender, up a few percentage points from 2021.

“It’s a culture war issue,” said Anne Whitesell, a political scientist at Miami University in Ohio who has studied gender and politics.

Whitesell said Republicans are united on transgender policy, while Democrats have found less consensus.

“The issue for Democrats is much thornier,” she said.

Whitesell said the political debate over transgender policies is a continuation of years of fighting about gay rights.

That fight was largely resolved when the Supreme Court decided same-sex marriage was legal in 2015, she said.

Just 1.3% of American adults identify as transgender, according to Gallup.

Loge said that makes transgender issues an easy target for Republicans.

Whitesell said transgender people aren’t a large voting bloc.

And a lot of voters don’t personally know a transgender person, so the political debates can become more symbolic than personal, both Loge and Whitesell said.

Loge said transgender issues, including sports participation, are complicated.

“It’s complicated medically. It’s complicated socially. It’s complicated in all sorts of ways. But ‘it’s complicated’ makes a terrible bumper sticker,” he said of the way the issue divides along political lines.

Trump’s order for his military transgender ban argued that “expressing a false ‘gender identity’ divergent from an individual’s sex cannot satisfy the rigorous standards necessary for military service.”

But a post-9/11 veterans group criticized the ban as targeting dedicated warriors “for the sake of scoring political points.”

And in the debate over transgender sports participation, a young woman who made headlines by taking a knee against a transgender competitor in a fencing bout told lawmakers that she felt “betrayed” and “unwelcome” in the sport she loved.

“That knee I took in protest was a cry for help and an act of desperation,” female fencer Stephanie Turner said in a congressional hearing last month.

Turner told lawmakers that biological males have an advantage with speed and power in her sport.

But in the same hearing, National Women’s Law Center CEO Fatima Goss Graves told lawmakers that transgender bans are discriminatory and, in her view, they hurt all women.

“As an expert in women’s rights in sports and in society, I want to be clear here: Transgender women do not pose a threat to women’s sports. Transgender women belong in sports,” Goss Graves said at the House hearing.

The Gallup poll found 90% of Republicans believe transgender athletes should only be allowed to play on sports teams that match their birth sex.

That view was held by 72% of independents and 41% of Democrats.

Gallup also asked if people should be allowed to use the gender they identify with on government documents, such as a passport or driver’s license.

Two-thirds of Americans said people should be required to use their birth sex on government documents.

The vast majority of Republicans, 89%, and a minority of Democrats, 38%, said people should be required to use their birth sex on government documents.

More Americans viewed being transgender as a decision that was influenced by a person’s upbringing and environment rather than factors the person had from birth, the Gallup poll showed.

That view was held by half of Americans, with another 30% telling Gallup that people are born as transgender. The remaining share of people either said it’s both nature and nurture, it’s neither, or they didn’t have an opinion.

Most Republicans, 76%, told Gallup they think a person is transgender based on upbringing and environment, not from birth.

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Esports team implements NCAA mental

June 10, 2025 Team launches training program in effort to ease burdens of competitive stress, academic pressure In accordance with new NCAA guidelines, UND has implemented a new mental health program for its esports teams, one that provides guidance to support the athletes’ mental well-being. UND archival photo. By Vanessa Washington “Psychological issues include depression, […]

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Esports team implements NCAA mental

Team launches training program in effort to ease burdens of competitive stress, academic pressure

UND students engaging in esports
In accordance with new NCAA guidelines, UND has implemented a new mental health program for its esports teams, one that provides guidance to support the athletes’ mental well-being. UND archival photo.

By Vanessa Washington

“Psychological issues include depression, anxiety, apathy, uncooperative attitude, tension, sleep disturbances, mental distress, aggressive affect and behaviors, distress in social life, and emotional disturbances,” the 2021 study declared.

The activity also “was associated with the presence of depression, social phobia, obsession–compulsion, interpersonal sensitivity, hostility, phobic anxiety, paranoid ideation, psychoticism attention-deficit hyperactivity disorder and gaming addiction.”

As that last item suggests, the activity being looked at by the Industrial Psychiatry Journal study is excessive gaming.

You see – and as UND’s Frank Swiontek and Ryan Kraus fully understand – there’s a lot more to video gaming than just relaxing with buddies and having fun.

Swiontek is the innovation officer at UND, and Kraus is the head coach of UND’s esports team. Make no mistake, esports athletes can experience significant stress; and during the team’s post-season contests last fall, Kraus and Swiontek say, that stress was starting to take its toll.

“At the time, playoffs were occurring, finals were kicking up, and we were starting to see the wear and tear that some of this competitive stress was having on these players,” Swiontek said. He and Kraus both noticed this, and in response, the two began researching what practices they could implement to help their athletes before the start of the spring season.

Mental-health poster for esports athletes
Photo by Vanessa Washington/UND Today

The NCAA’s mental-health toolbox

As they discovered, not much has been written about mental health guidelines for esports, one of the newest competitive activities for college athletes. But the NCAA itself, Kraus and Swiontek learned, has a new and useful mental health mandate for all NCAA athletes.

And that’s why this spring, UND’s esports team implemented mental health training, in an effort to ease the burdens of competitive stress and academic pressure. (Editor’s note: Posters such as the ones shown with this story, which hang in UND’s esports spaces, are a part of that effort.)

Here’s how the American Council on Education’s Higher Education Today reported the NCAA’s action last July:

“The NCAA, in consultation with its Mental Health Advisory Group, has released a new edition of Mental Health Best Practices, which provides guidance to support student-athletes’ mental well-being,” Higher Ed Today reported.

“NCAA member institutions are required to offer resources and services consistent with the best practices, which go into effect Aug. 1, 2024.”

All college athletes experience stress and anxiety, of course. But for esports athletes, the sport adds a few key stressors all its own: For one thing, the teams compete in both the fall and spring, which means players don’t have much of an “off season” in which to decompress.

For another, in esports competitions, players are subject to sudden death, meaning they can be “killed” and removed from the game in an instant. So, all esports athletes know that each game is an utterly unpredictable situation, one where they might be left standing almost alone.

As an esports player once put it, “We game to escape stress, only to be stressed out over the game.”

In such an environment, the stress can be heightened. This past semester was no different, except there was a new effort taken by UND

Stress 101: How to cope in healthy ways

The NCAA’s Mental Health Best Practices guide “emphasizes the importance of making high-quality mental health care available to student-athletes,” Higher Education Today noted in its story.

“It also recognizes that the dual roles of student and athlete can entail both unique mental health risk and protective factors. For example, injuries increase student-athletes’ risk of mental health symptoms, while relationships with teammates can fortify mental health.”

Armed with this knowledge, Kraus and Swiontek got in touch with Michael Herbert, a research data analyst in University Analytics and Planning, and Michael Soward, a doctoral intern in Clinical Psychology at UND’s Counseling Center.

From there, the esports leaders learned that they would first need to establish a few things. For example, they needed a plan for how they were going to present this new idea to their athletes, plus a description of just what that idea would involve.

They decided to begin with a quick hands-on course at the beginning of the semester to introduce the athletes to the free resources that are available to them. Next came the CCAPS, or Counseling Center Application of Psychological Symptoms. This is a 10-minute mental health screening in which the athletes answer questions.

Mental health poster for esports athletes
Photo by Vanessa Washington/UND Today

The screening can identify individuals who may be struggling with increased anxiety, depression, substance use and even suicidality.

“We’re able to identify those individuals who could benefit from additional support,” said Soward. “We report back to the coaches and let them know, and it then falls onto the coaches to reach out to those students.”

CCAPS offers other ways to identify what an athlete is going through, and one of these was introduced to the team captains at the start. It teaches how to start the conversation, how to engage team members about mental health and where teammates might be struggling, and how to identify those struggles in their teammates.

While Kraus is the head coach, there has been a big increase in athletes participating in esports; there are now close to 90 at UND. That means the team captains, given their closeness to the players, tend to be the most appropriate leaders to initiate these challenging conversations.

The program’s goal “is to nurture and keep all these athletes safe, especially in the mental health aspect,” Soward said.

From trial run to standard feature

While the spring conversations were a trial run for the program, team leaders were surprised by how many players took it seriously; in fact, they say, it was an overwhelming success. They were also surprised by how many athletes started watching out for one another after taking part in the training, the CCAPS element in particular.

“I’ve seen them become a lot more accepting,” said Kraus. “I’ve actually heard some students talk about it, especially when we were doing those tests.”

When asked what changes he hoped would result from this project, Swiontek said change wasn’t the goal. Instead, better awareness among the coaches and athletes was.

And if the team’s initial response to the project is any indication, that awareness seems likely to grow, through the fall esports season and beyond.

About the author:

A rising sophomore at UND, Vanessa Washington is an intern for UND Communications and UND Today.

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Fortnum & Mason, Ladbrokes, Beats, Bulldog and Huntsman

To continue enjoying this article, please sign in. You can register for free for limited further access. Register Limited free articles a month Free email bulletins Register now Take a 30-day free trial Get full access to all our subscriber-only content Unlock unlimited news, case studies and monthly masterclass videos Read our Deep dive insights […]

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Fortnum & Mason, Ladbrokes, Beats, Bulldog and Huntsman

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Simone Biles Fires Back at 'Sick' Transphobic Comments About Athletes

Simone Biles went toe-to-toe with political activist Riley Gaines after the former competitive swimmer allegedly made comments about transgender athletes playing sports. OutKick podcaster Gaines, 25, reposted the Minnesota State High School League’s Friday, June 6, X upload about winning a softball tournament. Advertisement Advertisement Advertisement “Comments off lol,” Gaines wrote on Friday. “To be […]

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Simone Biles Fires Back at 'Sick' Transphobic Comments About Athletes

Simone Biles went toe-to-toe with political activist Riley Gaines after the former competitive swimmer allegedly made comments about transgender athletes playing sports.

OutKick podcaster Gaines, 25, reposted the Minnesota State High School League’s Friday, June 6, X upload about winning a softball tournament.

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“Comments off lol,” Gaines wrote on Friday. “To be expected when your star player is a boy.”

In response, Biles, 28, called out the “Gaines for Girls” podcast host for her allegedly transphobic comments.

Simone Biles Explains Why It Was ‘Important’ to Stand Up for Teammates After MyKayla Skinner Comments

“@Riley_Gaines_  You’re truly sick, all of this campaigning because you lost a race. Straight-up sore loser,” Biles wrote later that day. “You should be uplifting the trans community and perhaps finding a way to make sports inclusive OR creating a new avenue where trans [people] feel safe in sports. Maybe a transgender category IN ALL sports!!”

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She added, “But instead … You bully them … One thing’s for sure is no one in sports is safe with you around!!!!!”

Gaines, in response, said that she found the Olympic gymnast’s comments to be “disappointing.”

“It’s not my job or the job of any woman to figure out how to include men in our spaces,” Gaines replied. “You can uplift men stealing championships in women’s sports with YOUR platform. Men don’t belong in women’s sports, and I say that with my full chest.”

Biles fired back, further defending the transgender community.

Simone Biles’ Most Honest Quotes About Mental Health and Wellness Through the Years: ‘We’re Human’

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“Bully someone your own size, which would ironically be a male,” Biles wrote, tagging Gaines’ account.

In subsequent tweets and comments, Biles continued to advocate for allyship while Gaines doubled down on her perspective. Neither has further addressed their differing points of view.

Biles, for her part, has long been a supporter of the LGBTIA+ community.

“The world we live in makes me sad, but I’d do x1000000 more commercials with you just to piss everyone off,” Biles wrote via X in November 2020, referring to an Uber Eats commercial she did with nonbinary Queer Eye star Jonathan Van Ness. “The LGBTQIA will always have my support and feel welcome on my socials.”

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Biles’ former teammates also praised her for advocating for others.

“After Tokyo, I said to [Simone], ‘There has to be so many people around the world that were suffering in silence and struggling with their mental health. You have no idea how many of those people you helped,’” retired gymnast Aly Raisman told Sports Illustrated in January. “She helps people feel less alone.”

In addition to supporting the LGBTQIA+ community, Biles has also shone a spotlight on mental health awareness. In 2020, she withdrew from the Olympic Games over mental health issues about suffering “the twisties” mid-competition.

“I have to focus on my mental health. I just think mental health is more prevalent in sports right now,” she said at the time. “We have to protect our minds and our bodies and not just go out and do what the world wants us to do.”

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Bryce Young's Camp Ignites Memories and Mental Health Conversations

Bryce Young, the No. 1 overall NFL draft pick, hosted the Young 9 Foundation’s CareSource Football Procamp, emphasizing mental health awareness for youth. Reflecting on his own childhood experiences with legends like Kobe Bryant, he’s committed to providing kids with memorable opportunities. This second annual camp featured Panther coaches and teammates, fostering a supportive environment […]

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Bryce Young's Camp Ignites Memories and Mental Health Conversations

Bryce Young, the No. 1 overall NFL draft pick, hosted the Young 9 Foundation’s CareSource Football Procamp, emphasizing mental health awareness for youth. Reflecting on his own childhood experiences with legends like Kobe Bryant, he’s committed to providing kids with memorable opportunities. This second annual camp featured Panther coaches and teammates, fostering a supportive environment for campers while instilling the significance of mental health. Young, raised in a household that valued emotional well-being, seeks to eliminate stigma for others and equip them with essential tools.

By the Numbers

  • This is the second year for the Young 9 Foundation camp in Charlotte.
  • Young hosted over 100 children at the Procamp.

State of Play

  • The camp occurred between OTAs and the Panthers‘ minicamp, creating a unique atmosphere amidst the NFL schedule.
  • Younger players, including teammates and coaches, participated to share insights and support the initiative.

What’s Next

As Young embarks on his third season with the Panthers, he aims to continue expanding the Young 9 Foundation’s reach and influence, with future camps and initiatives focused on youth mental health awareness.

Bottom Line

The Young 9 Foundation’s camp exemplifies Bryce Young’s dedication to mentoring youth and prioritizing mental health, highlighting the importance of giving back and fostering emotional resilience in the next generation.

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Olympic great Simone Biles shares mental health journey on first Hong Kong visit

Simone Biles has 11 Olympic medals and 30 World Championship wins. She is considered one of the best gymnasts of all time. Still, even she has to deal with negativity online. “That was hard for me to wrap my head around,” Biles, 28, told the audience during her first visit to Hong Kong last week. […]

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Olympic great Simone Biles shares mental health journey on first Hong Kong visit

Simone Biles has 11 Olympic medals and 30 World Championship wins. She is considered one of the best gymnasts of all time. Still, even she has to deal with negativity online.

“That was hard for me to wrap my head around,” Biles, 28, told the audience during her first visit to Hong Kong last week.

Reading such harsh words can be difficult, so she has learned to protect herself.

“When I’m not mentally well enough to read the comments, I turn them off or ignore them,” she said. She also reminds herself that many of these people are strangers: “They don’t know me, and they don’t know my character, so how can they judge through a screen?”

Biles spoke to more than 500 students at the one-hour event hosted by UBS. She talked about her record-breaking career and maintaining her mental health under public pressure.

As a professional athlete, taking care of your mental health is just as important as your physical health, Biles explained.

“Elite athletes [face] a lot of mental effort to step onto the big stage and compete for your country. Obviously, it’s such an honour, but it can be really tough,” she said.

More than 500 students came to see Simone Biles on her first visit to Hong Kong. Photo: Handout

Knowing when to step back

The training schedule of a professional athlete is challenging. Biles and her team train 32 to 34 hours a week. They do two workouts on weekdays and one on Saturday, taking only Sunday off.

Considering all this effort, Biles stunned the world at the Tokyo Olympics in 2021. She withdrew from several events, including the team final, all-around final, and individual event finals.

The reason for her decision was a mental condition called the “twisties”.

Having the twisties can make gymnasts feel like their rhythm is off and that they are not in control of their movements. It can lead to serious injuries.

Biles looks back on the experience positively. She is proud that she put her mental health first.

Sports psychologist discusses why teen athletes struggle to keep their head in the game

“It’s the most courageous I’ve ever felt,” she said. “The number one reason why I did it was to speak out and stand up for myself. I felt worth more than gold.”

Having a strong support system helped her feel confident about her decision. “My team, my family, the nurses and doctors and the mental health specialists, they all understood,” she said.

“Having people in your circle of trust that help you and you can confide in really, really helps,” she explained. “If I’m ever having a bad day, they let me have bad days, and they cheer me up. On the good days, they still uplift me.”

Biles competed at the 2024 Paris Olympics three years later. She took home three gold medals and one silver.

Simone Biles poses with her gold medal during the podium ceremony after the artistic gymnastics women’s all around final during the Paris 2024 Olympic Games on August 1, 2024. Photo: AFP/Getty Images/TNS

Meaning of mentorship

Biles is also passionate about supporting children in the foster care community.

She and her siblings entered foster care when she was only three years old. Their biological mom struggled with substance abuse. After a few years, Biles was adopted by her grandfather and his wife.

“I never let what happened to me stop me from believing in my dreams,” she said. “It doesn’t matter how you start; it matters where your journey takes you and how you walk that path.”

For the last few years, she has worked with Friends of the Children. The organisation partners with community organisations, schools, and foster care systems. They pair children in need of long-term, nurturing relationships with an older friend who acts as their mentor.

“A lot of people think that foster kids can’t do great things, but I think we’ve proven over so many years [we can]. Never let that determine who you are,” she said.

‘Fly High’ charity sports programme gets Hong Kong youth moving

Students who listened to her story said they were inspired. Fifteen-year-old Ila Chan has been on the Hong Kong gymnastics team since she was nine. She said her biggest takeaway was learning how to handle high-pressure situations.

“She should keep going because she’s an idol for lots of people around the world,” Ila said.

Lexie Rhodes, 12, has been doing gymnastics for around five years. She said she felt encouraged to recharge. She also learned the importance of letting off steam and taking the time to relax.

Biles appreciates the chance to serve as a role model, especially for young athletes. She offered up a tip for staying motivated and avoiding burnout: make sure you’re always having fun.

“You never know how long your career is gonna last,” she said. “So I would say to just have fun. Dream big, and then dream bigger after that. As long as you’re having fun, you can accomplish anything and love what you do.”

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elite 精英

to be highly skilled in a particular field

foster care 寄養照顧

a system in which children who cannot live with their biological family are moved into homes with temporary parents or carers

harsh 刻薄

cruel or unkind behaviour

withdrew 退出

to voluntarily quit a competition or event

confide 傾訴

to share personal thoughts or feelings with someone you trust

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