New research to be presented at this year’s European Congress on Obesity (ECO 2025, Malaga, Spain, 11-14 May) shows that around two thirds of participants of the SURMOUNT-1 trial had only regained 5% or less of their so-called nadir (or lowest weight) three years after beginning treatment with tirzepatide. The study is by Professor Louis […]
New research to be presented at this year’s European Congress on Obesity (ECO 2025, Malaga, Spain, 11-14 May) shows that around two thirds of participants of the SURMOUNT-1 trial had only regained 5% or less of their so-called nadir (or lowest weight) three years after beginning treatment with tirzepatide. The study is by Professor Louis Aronne, Comprehensive Weight Control Center, Division of Endocrinology, Diabetes, and Metabolism, Weill Cornell Medicine, New York, NY, USA, and co-authors from Eli Lilly and Company, Indianapolis, IN, USA, which funded the study.
Obesity management is a long-term journey during which fluctuations in body weight are expected to occur. For some patients, a previous nadir (or lowest) weight can become a point of focus (and disappointment when it cannot be reached again). However, there is not yet clear literature that nadir weight is clinically relevant. This post hoc analysis of the SURMOUNT-1 study, at 3 years, aimed to assess weight regain from nadir weight over 3 years (36 months / 176 weeks) with tirzepatide treatment.
The original SURMOUNT-1 trial was published in NEJM in 2022, and found that, across 72 weeks, participants with obesity treated with 5 mg, 10 mg, or 15 mg of tirzepatide once weekly experienced substantial and sustained reductions in body weight.
This analysis included 690 tirzepatide-adherent participants (65% female, 35% male) with a mean age of 49 years, a mean weight of 107 kg, and a mean BMI of 38.6 kg/m2 who were chosen from the original SURMOUNT-1 cohort on the basis they had been treatment-adherent across the 3-years (with 75% or more of planned doses received) and were living with obesity(a BMI of at least 30 kg/m²), or overweight (a BMI of at least 27 kg/m²) and prediabetes, and had been participants in the SURMOUNT-1 study and had lost at least 5% of their baseline weight when reaching their nadir weight (the lowest weight achieved during treatment).
Weight regain from nadir to Week 176 was defined as the difference between percent weight reduction from baseline to nadir and percent weight reduction from baseline to Week 176. Weight regain analyses were calculated as a mean across groups and were categorised as less than 5%, 5% to 10%, and 10% or more weight regain.
The analysis showed that the mean time to nadir weight was 22 months (96 weeks). The mean percent weight reduction at nadir weight was 23.1%. The mean percent weight regain from nadir weight to Week 176 was 3.7%, meaning that across the 690 participants over these three years there was a mean percent weight reduction of 19.4% (23.1% minus 3.7%).
At Week 176, 73%, 19%, and 8% of participants treated with tirzepatide 5 mg (227 participants) regained less than 5%, 5% to 10%, and 10% or more from nadir weight, respectively. Similarly, 65%, 26%, and 9% of participants treated with tirzepatide 10 mg (N=239) regained less than 5%, 5% to 10%, and 10% or more weight from nadir to week 176, respectively. Among participants treated with tirzepatide 15 mg (N=224), 73%, 20%, and 7% experienced less than 5%, 5% to 10%, and 10% or more weight regain from nadir to Week 176, respectively.
The authors have not yet analysed if there are any differences in weight gain between men and women or between older and younger participants.
This analysis found that 70% of participants treated with tirzepatide had limited weight regain – meaning 5% or less – after their nadir, or lowest weight. Less than 10% of participants regained 10% or more from their nadir weight. Overall, these findings suggest that most participants receiving tirzepatide had a relatively stable weight journey over 3 years in the SURMOUNT-1 3-year study, and managed to avoid any substantial weight regain.”
Dr. Louis Aronne, Comprehensive Weight Control Center, Division of Endocrinology, Diabetes, and Metabolism, Weill Cornell Medicine
European Association for the Study of Obesity
Jonathon Miller was recently inducted into the National Semi-Pro Baseball Hall of Fame on July 26 in Dayton. Miller is a 1999 graduate of Bellefontaine High School. He was also a backup quarterback at the University of Louisville. Miller has founded Project Purple which helps children of those dealing with mental health and addiction issues. […]
Jonathon Miller was recently inducted into the National Semi-Pro Baseball Hall of Fame on July 26 in Dayton.
Miller is a 1999 graduate of Bellefontaine High School. He was also a backup quarterback at the University of Louisville. Miller has founded Project Purple which helps children of those dealing with mental health and addiction issues.
In October of 2026, Miller will be inducted into the Ohio Sports Hall of Fame along with his former baseball coach Lou Brunswick.
Getty Images Advil. A name every athlete is familiar with. It’s the first response to a sore muscle and the go-to fix after a tough meet. But its presence also marks the beginning of a deeper issue that lies within competitive sports – the normalization of medicating pain, even when the pain is more than […]
Advil. A name every athlete is familiar with. It’s the first response to a sore muscle and the go-to fix after a tough meet. But its presence also marks the beginning of a deeper issue that lies within competitive sports – the normalization of medicating pain, even when the pain is more than physical.
As a high school track and field athlete, I’ve watched my teammates deal with injuries like shin splints, tendon strains, and hamstring pulls, often continuing to train through them. Behind the scenes, pain management becomes a silent routine: over-the-counter anti-inflammatories, muscle rubs, taped joints. And when that’s not enough, some athletes receive prescriptions for something stronger. Not to escape the pain, but to function and perform.
Opioid misuse among athletes, especially those recovering from injury, has emerged as a national concern. A study published in the Orthopaedic Journal of Sports Medicine found that 26.5% of collegiate athletes had received an opioid prescription following an orthopedic injury or surgery, along with a small subset using opioids for non-pain relieving purposes.
What makes opioids especially dangerous in athletic environments is not just their addictive potential; it’s the culture surrounding them. Athletes are taught to always “push through.” Recovery is treated as a delay to success, not a necessity. And vulnerability, especially among male athletes, is often condemned. Within this culture, asking for help or admitting something’s wrong becomes 10 times more difficult.
While national conversations about addiction often focus on unlawful substances or post-career collapse, the path to opioid dependency in sports begins earlier. For many, it starts with a legal prescription issued after an injury. A JAMA Network Open study from 2020 confirmed that young athletes, particularly those in high-intensity sports, face an elevated risk of extreme opioid use compared to non-athlete peers.
What separates sports-related opioid addiction from other contexts is that athletes often aren’t seeking a frenzy, but instead they’re seeking a return to ordinary. Opioids for athletes serve as a way to meet expectations. When recovery time is seen as lost time, performance becomes the priority over long-term health.
Professional sports provide some of the most visible cautionary tales. In the National Football League, the issue is so widespread that a class-action lawsuit was filed against the league by former players claiming that teams recklessly distributed opioids and other painkillers to keep them playing. In Olympic history, several elite athletes have revealed post-retirement battles with substance dependence all stemming not from recklessness, but from repeated injuries and a system that emphasized resilience over recovery.
In track and field specifically, the pressure to maintain peak performance over narrow competition windows creates a cycle of overtraining, underreporting pain, and constant reliance on medication. As the Olympics approach every four years, the spotlight grows more intense. Even among youth athletes, the drive to qualify for state and national competitions or college recruitment can lead to several shortcuts being taken and, in extreme cases, substance use.
Addiction isn’t a personal failure but, in the bigger picture, it’s a systemic blind spot. It grows from environments that prioritize output over well-being. Until sports organizations, schools, and coaches build stronger frameworks around injury care, mental health, and education, this pattern will only continue.
The stigma surrounding athlete weakness must be broken down. Opioids don’t appear out of nowhere, rather they fill gaps left by pressure and insufficient support.
I’ll always love the thrill of track from the adrenaline to the discipline and competition. But no race is worth losing oneself. In a network built on pushing limits, real change begins by recognizing where we’ve pushed too far.
This article was written as part of a program to educate youth and others about Alameda County’s opioid crisis, prevention and treatment options. The program is funded by the Alameda County Behavioral Health Department and the grant is administered by Three Valleys Community Foundation.
Spencer Stastney, a defenseman for the Nashville Predators, contemplated retirement before the 2024-25 season due to significant mental health struggles. His challenges peaked after the 2024 Calder Cup Playoffs, compelling him to consider leaving the sport at just 24. Despite a promising start to his career with notable performances in both the AHL and NHL, […]
Spencer Stastney, a defenseman for the Nashville Predators, contemplated retirement before the 2024-25 season due to significant mental health struggles. His challenges peaked after the 2024 Calder Cup Playoffs, compelling him to consider leaving the sport at just 24. Despite a promising start to his career with notable performances in both the AHL and NHL, feelings of anxiety led Stastney to seek help through the NHLPA’s Player Assistance Program. After a hiatus from training camp, he returned to the ice in December, performing well enough to earn an NHL call-up. Stastney aims to continue his career with the Predators as he navigates his relationship with the sport.
By the Numbers
State of Play
What’s Next
Stastney will focus on re-establishing his career with the Predators, aiming for a full-time NHL position as he continues to tackle mental health issues. His performance will be closely monitored as he aims to solidify his role within the organization.
Bottom Line
Stastney’s journey highlights the importance of mental health awareness in sports. His openness to discuss and seek help showcases resilience and may foster a culture of support among athletes facing similar challenges.
Andrea Spendolini-Sirieix will not compete at this month’s World Aquatics Championships due to “mental blocks”. The 20-year-old diver claimed Olympic bronze with Lois Toulson in the women’s synchronised 10m platform at Paris 2024 and opened up about her mental health struggles after competing in the individual event. On Wednesday Spendolini-Sirieix revealed she would not be […]
Andrea Spendolini-Sirieix will not compete at this month’s World Aquatics Championships due to “mental blocks”.
The 20-year-old diver claimed Olympic bronze with Lois Toulson in the women’s synchronised 10m platform at Paris 2024 and opened up about her mental health struggles after competing in the individual event.
On Wednesday Spendolini-Sirieix revealed she would not be taking part in the World Championships, saying she feels “it would be best” to take a break from the sport.
She said in a post on Instagram: “Unfortunately, I won’t be attending the World Championships this year in Singapore. I’ve had a tough battle with mental blocks in diving this season, and I’ve tried to fight through them, but I’ve decided it would be best for me to take a break from the pool.
“I am getting all the help I need from my family, my coach and my support team at Aquatics GB and I am so thankful for their love and support.
“As an athlete, the words ‘rest’ and ‘break’ are foreign, but I know that this period will greatly help me in the long run.
“I am sad to not be joining my team and international friends out in Singapore, but I know they will do amazingly and I can’t wait to see them shine.”
PA
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AFC players are making headlines with their evolving situations. Charvarius Ward of the Colts reflects on his mental health journey following personal loss, sharing renewed optimism after leaving the 49ers. Meanwhile, Texans tight end Brevin Jordan is ready to bounce back from a torn ACL, while Titans rookie QB Cam Ward acknowledges the team’s need […]
AFC players are making headlines with their evolving situations. Charvarius Ward of the Colts reflects on his mental health journey following personal loss, sharing renewed optimism after leaving the 49ers. Meanwhile, Texans tight end Brevin Jordan is ready to bounce back from a torn ACL, while Titans rookie QB Cam Ward acknowledges the team’s need for improvement and accountability. Collectively, these narratives illustrate resilience and the ongoing adjustments as teams prepare for the season ahead.
By the Numbers
State of Play
What’s Next
As the season approaches, all eyes will be on how these players integrate into their teams. Ward’s positive changes in mental health could set the tone for a successful Colts season, while Jordan’s return may bolster the Texans’ offense. Titans’ rookie Ward’s commitment to improvement suggests he will work to elevate the team’s performance.
Bottom Line
The resilience shown by these AFC players amidst personal and team challenges underscores the importance of mental health and adaptation in professional sports. As they move forward, their experiences highlight how personal growth can impact team dynamics and performance.
Kyrie Irving, standout guard for the Dallas Mavericks, has opened up about experiencing bullying in his childhood, which became a driving force behind his basketball journey. During a livestream with Kai Cenat, Irving candidly shared that being perceived as smart and sensitive made him a target, but he channeled that adversity into motivation for his […]
Kyrie Irving, standout guard for the Dallas Mavericks, has opened up about experiencing bullying in his childhood, which became a driving force behind his basketball journey. During a livestream with Kai Cenat, Irving candidly shared that being perceived as smart and sensitive made him a target, but he channeled that adversity into motivation for his NBA career. Despite this challenging background, he has risen to elite status in the league, demonstrating remarkable skills and leadership. Recently, Irving has also been active in online discussions, reflecting on his journey and future ventures, including a possible coaching role.
By the Numbers
Yes, But
While Irving’s bullying experience contributed to his resilience, it also highlights ongoing issues of childhood bullying and mental health in sports, stirring debate about the pressure athletes face both on and off the court.
State of Play
What’s Next
As Irving navigates his recovery from injury, he may also explore a coaching future, which could reshape his career beyond playing. Fans and analysts will be watching closely to see how he impacts both the Mavericks and any potential new ventures.
Bottom Line
Irving’s journey underscores the idea that personal hardships can motivate success, but they also raise important conversations about youth bullying and the mental health challenges athletes face. His future, both on and off the court, is poised for scrutiny and potential innovation.
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